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PLoS ONE 8 , e58764 (2013)

It is the FDAs way of flagging a substance that may present significant safety risks when used in compounding

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Individual metabolism: Some people process caffeine and supplements more quickly than others

[3] Initial treatment of pernicious anemia typically consists of 1,000 mcg intramuscularly daily for one week, then weekly for four weeks, transitioning to 1,000 mcg monthly for life

vant Hoff WG, Gretz N (1995) The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire