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Here, we will review the current understanding of how GLP-1 and ghrelin regulate insulin secretion in the pancreatic islet -cells, and insulin action in the vagal afferent neurons and hypothalamic arcuate nucleus (ARC) neurons, the interfaces between the peripheral metabolism and brain

Conclusion The present review has summarized the current clinical evidence for a potential use of GLP-1R agonists in prospective neuroprotective treatment strategies against glaucoma and other neurodegenerative diseases

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