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It separately names personal or family history of medullary thyroid cancer and multiple endocrine neoplasia type 2 as absolute contraindications
Patients are regularly evaluated by the care team to track weight trends, metabolic health, and potential side effects
The brand-name Mounjaro and Zepbound labels include dosage options up to 15 mg per week, with intermediate steps at 10 mg and 12.5 mg
The GIP receptor component adds a second layer
Oral dosing has specific timing instructions (for example, taking it on an empty stomach with a small amount of water and waiting before eating), because absorption can be sensitive
In all, around 6% of Zepbound users and 8% of Wegovy users left the trial due to side effects, AP said in a report
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