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Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus calmette-guerin
Exact mechanisms for the stimulation of NADPH oxidase are complex but are known to occur at the genetic, transcriptional, and post-transcriptional levels and involve numerous signaling molecules and scaffolding proteins/platforms [62]
Dose escalation followed a stepwise schedule, progressing from 2 mg up to a maximum of 12 mg once weekly over several months, depending on tolerability
Soni S, Kaur G
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