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Although description of gonorrhea-like symptoms dates back to ancient civilizations like the Romans, Jews, and Arabs, genomic analysis suggests that the modern gonococcal population originated much more recently, possibly in the 16 th century, and was subsequently spread globally (Golparian et al., 2020)

Downregulation of ATP5A1, the ATP Synthase F1 Subunit Alpha [123], and ATP5G3, the ATP synthase F0 complex subunit C3 [124], was observed in the postmortem study of ASD patients in all examined regions [122], which could inhibit the activity of complex V [79] and promote the ETC breakdown due to opening of the mPTP [125, 126]

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Safety considerations are critical in determining treatment duration