The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)
GLP-1 Receptor agonist was proved by the Action Control Cardiovascular Risk in Diabetes trial (ACCORD) 75% decrease death rate in patients under Exentide treatment
Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD
Each year, RA has a devastating financial impact of $50 billion in lost productivity and health care costs [1]
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