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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]
[published correction appears in Obes Facts
In comparing their blood samples with those of 45 demographically matched healthy people, the depressed patients' acetyl-L-carnitine blood levels were found to be substantially lower
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Petersen, K.F., et al., 2021
Some research shows that L-carnitine can decrease cholesterol levels, but other research shows no benefit
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