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Age-related sarcopenia, hormone decline, and GLP-1-induced weight loss create a triple threat to lean mass
Combination GABA with GAD immunization increased the duration of syngenic -cell survival in diabetic NOD mice from 1 week in control-diabetic mice to 10 weeks with maximal GABA doses (GABA 6 ml/ml in drinking water + 100 mg GAD immunization) (49)
The GLP-1 and GIP effects on pancreatic beta cells may also improve insulin secretion capacity beyond the effects of weight loss alone
That's a significant oversight, because the organ that may benefit most from creatine isn't the one you're training on leg day
Importantly, targeting cholesterol biosynthetic enzymes such as CYP51A1 can influence ferroptosis independently of metabolite levels, implying that these enzymes may have non-canonical, cholesterol-independent functions in ferroptotic regulation