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It included a box warning regarding the risk of thyroid C-cell tumors with contraindications for patients with: A personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 Serious hypersensitivity to tirzepatide or any Zepbound excipients Monitoring is encouraged to look for symptoms of thyroid tumors, such as a lump in the neck, unexplained hoarseness, trouble swallowing, and shortness of breath
It is mostly produced in the pancreatic -cells in response to fasting or hypoglycemia, but some production occurs in the small intestine [11]
It builds up, causing bloating, pressure, discomfort, and often triggering nausea in people who are already prone to it on tirzepatide
Arch Ital Urol Nefrol Androl 1992
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