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That figure exceeds the Phase 2 result of 24.2% at 48 weeks, which was already among the largest body-weight reductions reported in a randomized obesity trial

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Based on further evidence found in HEK cells, it appears that a mechanism that depends on Gq might trigger the activation of protein kinase C (PKC) and ERK 1/2

Changes in urine production, swelling in the legs, ankles, or feet, and weariness are all signs of kidney damage