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Studies indicate that in the absence of appropriate medical intervention, approximately 20% of patients with diabetic wounds will require lower limb amputation, with a subsequent one-year mortality rate of 13% post-diagnosis 19,20
however, concomitant metformin therapy was not associated with an increased risk of GI symptoms, or an increased likelihood of GLP-1 RA discontinuation, compared to those who were not taking metformin
Similarly, Ni et al
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