Narang VS, Pauletti GM, Gout PW, Buckley DJ, Buckley AR
Data from pregnancy registries indicate infants exposed to topiramate during pregnancy have an increased risk for cleft lip and/or cleft palate and for being small for gestational age (SGA), defined as a birth weight below the tenth percentile
It describes how cautious researchers reason about an unproven pairing, not a recommended human protocol
Its also a useful longevity tool for supporting long-term weight management
His work focuses on how microbial ecosystems interact with human physiology, including: Gut barrier function and intestinal permeability Mucus-associated microbiota (Akkermansia-related systems) Oralgut microbiome axis Short-chain fatty acids (SCFAs) and metabolic signaling Circadian rhythmmicrobiome interactions Clinical Research Contributions He has contributed to multiple clinical-stage microbiome programs, supporting bacterial strain discovery, optimization, and formulation design across different therapeutic areas, including: Active Ulcerative Colitis (Inflammatory Bowel Disease) Hyperoxaluria (Oxalate Metabolism Disorder) Microbiome-driven gut health and inflammatory conditions These studies were part of broader clinical development programs evaluating microbiome-based approaches

In a crossover study of healthy men who received a 2-hour infusion of synthetic human GLP-1, there was a 19% decrease in circulating angiotensin II levels, but no change in plasma levels of renin or aldosterone [67], and no alteration in renal hemodynamic function [67]