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Furthermore, L-theanine and its semi-synthesized derivative (R)-2-(6,8-dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic ethyl ester (DTBrC) also restrained the growth and migration of human hepatocellular carcinoma (HHC) cells in in vitro , ex vivo , and in vivo HHC models, and the mechanism of this effect was that L-theanine and DTBrC blocked the Met/EGFR/vascular endothelial growth factor receptor (VEGFR)-Akt/NF-B pathways (72)

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Upton et al., 1998)