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Clinicians should: Assess baseline HbA1c and current glycemic control before discontinuation Implement or intensify alternative therapies (metformin, SGLT2 inhibitors, or other agents) before or concurrent with tirzepatide cessation Increase home glucose monitoring frequency for several weeks post-discontinuation Schedule follow-up to evaluate metabolic stability Special consideration for insulin or sulfonylurea users : Patients taking these medications alongside tirzepatide may need proactive dose adjustments when stopping tirzepatide to prevent hypoglycemia

Subcutaneous The subcutaneous (SQ) route injects the medication into the adipose tissue, the loose connective tissue directly under the dermis

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There are evidence that microglial cells also secrete GLP-1 in mice