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These results although distinct, didnt reach statistical significance

In animal experiments, the GLP-1RA liraglutide was found to stimulate the secretion of ANP by increasing the levels of Epac2, which is a downstream target of GLP-1R signaling in cardiomyocytes (132), However, this finding seemed to contradict the results of clinical studies in which no increase was observed in the levels of ANP in healthy people and patients with T2MD

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Saxenda for weight management), and oral semaglutide (Rybelsus) are prescribed under NICE guidance for specific clinical indications

While injectable medications such as Ozempic, Wegovy, Mounjaro, and Zepbound remain widely used, several oral GLP-1 medications are now available

GLP-1 medications carry black box warnings and potential side effects - commonly including nausea, vomiting, diarrhea, constipation, and abdominal pain - and require ongoing medical supervision