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Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
For instance, Zou and colleagues designed a disulfide cross-linked nanocapsule (Ang-NCss-siRNA) to deliver small interfering RNA (siRNA) specifically to glioblastoma (GBM) cells
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Escalate: Double the dose every 2 weeks (0.6 1.2 2.4 4.5 mg) as tolerated
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