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"A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S -transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase" (PDF)

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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes