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These include achieving efficient gene delivery to ensure the genes reach a sufficient number of target chondrocytes, precisely controlling long-term gene expression to maintain a stable therapeutic effect, and addressing potential immune responses triggered by the vectors

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Concurrently, SFN altered the adaptive immune balance by increasing the proportion of pro-inflammatory Th17 cells and decreasing the Treg/Th17 ratio

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Because P-5-P does not require enzymatic conversion in the liver, it is immediately available for use in the transsulfuration pathway and does not carry the same toxicity risks associated with high-dose pyridoxine