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Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome

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In particular, ECL1 and ECL3, which were disordered in the previous TMD structure, are now ordered and form a -helical conformation reminiscent of the peptide-bound GLP-1R structures

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GLP-1 therapies act comprehensively on this metabolic substrate, simultaneously addressing insulin resistance, hepatic inflammation, adipokine dysregulation, and systemic oxidative stress