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Geddes, J
Collectively, emerging evidence suggests that the most effective approach to prevent muscle wasting during GLP-1RA therapy combines nutritional and exercise strategies, with a multidisciplinary clinical management involving physicians, dietitians and exercise specialists to tailor interventions based on individual goals, comorbidities and age
Therefore, the lipid-lowing effects of dietary L-carnitine supplementation in the present study are likely to be caused by increased mitochondrial FA -oxidation activity and decreased lipid synthesis, which was in consistent with some mammalian studies 32,33
The identification of novel therapeutic strategies targeting amino acid pathways could allow for the emergence of new drugs and enhance the current therapeutic efficacy
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