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First, it is an endogenous molecule: it circulates in human plasma at a concentration of roughly 200 ng/mL around age 20, declining to about 80 ng/mL by age 60, a fall that has been linked, at least associatively, to the general decline in tissue regenerative capacity with age
New England Journal of Medicine, 393(1), 41-54
Generally well-tolerated when prescribed and monitored by a healthcare professional
Neurotoxicology 50:131141
Over-the-counter multivitamins do not have this much vitamin B12
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