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Single-peptide therapy often supports one part of that network well, then stalls when other constraints take over

For instance, when measuring nitric oxide levels immediately post workout, citrulline alone actually outperformed citrulline + glutathione, and several other parameters failed to reach statistical significance

This is the most overlooked factor

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Tian Y, Jing G, Zhang M (2023) Insulin-degrading enzyme: roles and pathways in ameliorating cognitive impairment associated with Alzheimers disease and diabetes