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Discussion should include gastrointestinal tolerance, dehydration risk, and the patients cardiovascular profile
While the overall risk appears to be small, I now screen more carefully for patients with risk factors such as pre-existing optic nerve problems, glaucoma, or significant diabetic retinopathy. Recent research also connects liraglutide, the active ingredient in Saxenda and Victoza, to similar concerns
About the review The present Review summarizes evidence from major randomized trials and clinical development programs in the field, drawing on literature identified through database searches including PubMed and focusing on key advances reported through October 2025
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According to our in silico predictions, the changes in metabolic fluxes in the mutant significantly impacted arginine synthesis and pathways related to NAD metabolism, indicating a redistribution toward stress protection in response to decreased glutathione content
Endocr Rev 41:bnz002
