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Glutathione deficiency is rare outside specific clinical contexts: chronic liver disease, HIV/AIDS, sepsis, or genetic disorders affecting glutathione synthesis (glutathione synthetase deficiency)

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It may be stated that it acts as a neurotransmitter or neuromodulator on adjacent GLP-1R-expressing nerve fibers, enhancing attraction to sweet tastes and contributing to residual sweet perception even in the absence of T1R3 (15, 18)

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Andrews SN, Jeong E, Prausnitz MR

Role of the Keap1-Nrf2 pathway in cancer