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These compounds contain cobalt in a corrin ring
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It is also being investigated for its potential benefits in cognitive function and as a supportive treatment during chemotherapy
These cardiovascular benefits may reduce the risk of heart disease, stroke, and other cardiovascular complications associated with obesity and metabolic dysfunction
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A 2006 review summarised the state of the field bluntly, describing the molecule as an unresolved riddle decades after its discovery (PMID 16539679)
Thus, whilst the CVOTs provide valuable and supportive evidence of a benefit of GLP-1 RAs on HF in people with type 2 diabetes, additional trials are required to fully understand the magnitude and nature of such a potential effect, including if it applies to both prevention and treatment of the condition
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