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Low levels of vitamin B12 (vitamin B12 deficiency)

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27 Under hypoxic conditions, intervened by hypoxia-inducible factor (HIF), there is a reduction in hepcidin expression, which promotes iron release

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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

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Concurrently, ROS oxidatively modify tau protein, enhancing its hyperphosphorylation and subsequent aggregation into neurofibrillary tangles, thereby disrupting microtubule stability and axonal transport [334]

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