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Compared with the RA group, the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups were able to significantly reduce the population of M1 macrophages and increase the population of M2 macrophages, among these groups the improvement was most significant in the MNs/GLP-1RAs@NPs-WYRGRL group (Fig

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The enzyme DPP-4 clips GLP-1 at the N-terminus, inactivating it