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[22] [23] Readers should check the current NICE technology appraisal status and local NHS commissioning arrangements before assuming availability, as guidance may have been updated since this article was prepared

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The version most commonly used in research is CJC-1295 without DAC (Drug Affinity Complex), which has a shorter half-life and is often preferred for more controlled research protocols

Regarding the central mechanism of feeding regulation, proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are key anorexigenic neurons

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