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The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator

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doi: 10.4314/ajtcam.v15i1 87 BellamkondaRRasineniKSingareddySRKasettiRBPasurlaRChippadaARet al

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