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This is relevant because muscle-related concerns with tirzepatide are common, and understanding how BMI category affects body composition changes helps set appropriate expectations

The eluted sample was quickly neutralized by addition of 1/10 volume of 1 M Tris pH 8.0 and further polished on a size-exclusion chromatography column (Superdex 75, GE healthcare) pre-equilibrated with phosphate-buffered saline (PBS, pH 7.4)

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Es importante resaltar que esta reduccin de HbA1c es consistente y que se observa tanto en los pacientes que asociaron lixisenatida a insulina basal previa, como en aquellos que iniciaron el tratamiento combinado desde el principio, independientemente de que estuviesen tomando o no sulfonilureas

*These data are based on self-report and are therefore prone to possibly inaccurate memory