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The ability of mitochondria to rapidly adapt to stress, including stress imposed by antimetabolites such as 5FU, means that they have significant potential to dictate therapeutic responses 11

435 We look forward to subsequent translational studies to identify specific baseline or post-treatment biomarkers that may more accurately predict subgroups sensitive to olaparib therapy

Without sufficient glutathione, cells become more vulnerable to damage

FIGURE 1 Although both animals and humans possess endogenous antioxidant defense systems, the prevailing view remains that additional antioxidant support must come from exogenous sources, particularly diet

In most of the study patients (95.0%), the primary lesions were solid tumors (Lung, Breast, Stomach, Colon, Uterus, Liver, Prostate, Ovary, Pancreas) and 61.7% had advanced cancer with metastatic lesions and 34 patients had co-administered standard care (mostly chemo)