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Clinical data shows that approximately 1520% of semaglutide users experience some form of injection site reaction, though severe cases requiring treatment discontinuation remain rare

Their glucose-lowering effect is generally more modest, and most members of this class are considered weight neutral

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However, the employer has significant financial risk

Based on clonidine and/or arginine growth hormone stimulation tests, 12 patients were diagnosed with GHD (peak GH below 7.5 ng/ml) and 8 with idiopathic short stature (peak GH above 7.5 ng/ml)

Third, individual-level patient data (IPD) were not available, limiting our ability to adjust for important confounders such as smoking, alcohol intake, family history, and genetic risk