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For people with cobalt allergy (which is more common among people with nickel allergy) who are also at risk of vitamin B12 deficiency, the "general advice seems to be 'take just enough but not too much,' which isn't too different from dosing advice for all vitamins and drugs" (via ACSH)
Vegans and vegetarians are naturally at higher risk since B12 comes mainly from animal products
The people who are at the highest risk of B12 insufficiency or deficiency are older adults, those with atrophic gastritis, gastrointestinal disorders, pernicious anemia, those who have had gastrointestinal surgery, vegans, and vegetarians
Serious adverse reactions, including cardiac arrhythmias and seizures, may occur with excessive systemic exposure
Therefore, dietary interventions are emerging as highly promising avenues of exploration in the realm of MDD
It sounds so inconvenient and annoying
