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Seek medical advice if you: cannot keep fluids down are urinating much less than normal feel severely weak or dizzy experience persistent vomiting or diarrhoea develop signs of significant dehydration Potentially serious complications can include: acute pancreatitis gallbladder problems severe gastrointestinal reactions dehydration-related kidney injury serious allergic reactions low blood sugar when combined with insulin or certain diabetes medicines worsening diabetic retinopathy in susceptible patients sudden or rapidly worsening vision problems The MHRA advises patients to seek urgent medical help for severe, persistent abdominal pain that may spread to the back, as this can be a sign of acute pancreatitis

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Patients with the following conditions should avoid FDA-approved semaglutide products: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Severe allergic reactions to semaglutide History of pancreatitis Diabetic retinopathy Kidney problems Serious stomach issues Pregnancy or breastfeeding Compounded semaglutide , lacking FDA approval, does not have the same established safety guidelines or defined patient populations

References Bergmann, N

Two-thirds of GLP-1 users reported reduced spending at restaurants, bars and fast-food chains

That discrepancy is the core of the concern