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Melanotan 2 selectively binds to the melanocortin receptor MC1R, which regulates the conversion of tyrosine into eumelanina brown-to-black pigment that effectively absorbs UV rays and disperses them in the skins surface layers, actively protecting epidermal cells from oxidative stress

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This phenomenon triggers a signal that leads to the fusion of the GLUT4-containing vesicles with the plasma membrane

at the cellular level, the targeted delivery system can accurately regulate the inflammatory signaling pathway and cell death program

Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P: Sitagliptin exerts an antinflammatory action