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Unfortunately, these materials are not specific, and their mechanism of action is based on the reduction of free radicals (Rea et al., 2009

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It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40

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DeSantis A (2020): Sodium-glucose co-transporter 2 inhibitors for thetreatment of hyperglycemia in type 2 diabetes mellitus