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Dose selection in the research literature varies with the application: musculoskeletal-injury studies commonly report 200250 g twice daily near the affected site, while gastrointestinal-focused protocols use 250500 g once or twice daily, subcutaneously

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[5] [6] Once administered intramuscularly (usually into the deltoid or gluteal muscle), hydroxocobalamin is rapidly absorbed into the circulation

A typical approach is 4 to 12 weeks on, then an off-cycle of equivalent length