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These compounds support the body's own system for the maintenance of cell function as we age

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For example, AZD8055 conjugated to albumin-stabilized gold nanoclusters (ABN-AZD) achieved tumor-selective drug release through glutathione-responsive linkers, 445 whereas albumin-bound rapamycin nanoparticles (nab-rapamycin, ABI-009) enhanced tumor accumulation and reduced systemic toxicity

In addition, GLP1/E and GLP1/GIP/Glucagon significantly improved insulin sensitivity, as denoted by ITT and HOMA-IR index, and decreased insulin levels

Thus, trained immunity is a double-edged sword, its net effect depends on whether it enhances or aggravates the tissue response