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Chemical modifications, such as amino acid mutations, addition of fatty acid chains, or design of synthetic analogs, can enhance their resistance to enzymatic degradation and significantly improve metabolic stability and half-life (Yu et al., 2018

The dual mechanism made a real difference for me. Megan A

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Obesity 19(3):581587 Wei D, Hsiao C, Johnston S (2018) Costs of complications in laparoscopic bariatric surgery

After all, people with obesity have more muscle mass than people without obesity (because their bodies carry more weight), so it's normal to lose muscle when you lose weight whether by diet, exercise, medications, or surgery

Even today, a patient of mine hesitated to start her FDA-approved bioidentical hormones because of that warningdespite struggling with severe hot flashes