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Tirzepatide doses of 10 mg and 15 mg resulted in lower body weight reductions of 12.8% and 14.7% respectively in individuals with overweight or obesity and T2DM [121]

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In the context of transcriptomic analyses, it is generally observed that GST expression is downregulated in susceptible interactions ( A

Preclinical studies in diet-induced obese (DIO) mice showed that once-weekly administration of the PEGylated GLP-1R/GcgR co-agonist for 1 month dramatically lowered body weight, compared with vehicle treatment [17]

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