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As a melanocortin receptor ligand, Melanotan 2 is used as a reference compound in non-clinical studies

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Assessment of seminal oxidative stress

Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

Cardiovascular side effects, while less common, may include changes in heart rate, with some patients experiencing a mild increase in resting heart rate of two to three beats per minute on average

Khor, B., Gardet, A