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Beyond defining a mitochondrial mechanism for fuel switching, this work provides a conceptual landscape for future investigation of metabolic adaptation across diverse physiological contexts, including exercise, distinct fasting paradigms, and hormone-driven metabolic regulation, and offers new insight into the determinants of responsiveness to GLP1R agonist-based anti-obesity therapies

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NICE recommends monitoring response to treatment through clinical assessment and blood tests as appropriate

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Additional analyses may include assessment of compound stability, consistency across experimental replicates, and observation of downstream cellular responses in regulated in vitro systems