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What the research shows: A phase 2 randomized, double-blind, placebo-controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) enrolled 338 adults with obesity
The consistent theme is restraint: hold the per-dose amount steady, use frequency and cycle structure as the adjustable variables, and build in breaks
Zhou, Y
When your goal is weight loss , it can feel like an uphill battle
DSIP also influences circadian rhythms related to pain perception
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