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Data were processed with the XDS program package 28

Meanwhile, MAPK/ERK signaling facilitates endothelial cell proliferation by phosphorylating downstream effectors such as c-Fos and Elk-1, which regulate the expression of pro-proliferative genes

Dual-axis tomograms were reconstructed from pairs of image stacks using the Etomo program within the IMOD software package (version 4.9.7)