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Glucagon-like peptide-1 (GLP-1) receptor agonists are injectable medications that mimic a naturally occurring hormone in the body

16.1% on semaglutide Tirzepatide was superior on all five key secondary endpoints Gastrointestinal discontinuation rate was lower with tirzepatide (2.7%) than semaglutide (5.6%) These findings were consistent across all patient subgroups, regardless of sex, age, baseline BMI, or presence of metabolic comorbidities

JAMA / New England Journal of Medicine (2010) 2

The goal remains optimizing diabetes management or weight loss while maintaining acceptable tolerability and patient well-being

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