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Lancet Diabetes Endocrinol 3(5):367381 van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidneyfrom mechanisms to clinical outcome

In clinical trials, participants are escalated through increasing doses over weeks under medical monitoring

Reconstituting in bacteriostatic water (pH approximately 4.5 to 7.0) is preferable to alkaline solutions, which can accelerate peptide hydrolysis and copper deposition

Many of the studies in the review were done on animals, and the ones that involved humans were small

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