Interestingly, although there is no benefit to using metformin to treat NAFLD, metformin seems to be effective for NAFLD-related complications: dose-dependent reduction in hepatocellular carcinoma (HCC) was demonstrated in a large cohort of diabetic Taiwanese patients [51, 52] with a 7% reduction in the risk of HCC per year of metformin use
Based on characteristic serological markers of HT, a prospective clinical trial demonstrated that Se supplementation reduced TPO-Ab titers and improved the quality of life of patients (56)
the Companys need for substantial additional financing
In sensitivity analyses removing the only trial restricted to patients with an acute coronary syndrome (ELIXA), all benefits marginally increased, including the outcome of worsening of kidney function, based on eGFR change (HR = 0.82
To put that into perspective, if starting BMI was 32, a 16% reduction would bring it down to 27
Besides, no other behavioral or clinical differences were observed among the three tested groups (Fig