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While vitamin D and omega-3 supplements are generally safe for most people when taken together, certain groups may need to exercise caution

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They include: 1) humanin, encoded by the 16S rRNA region of mtDNA (Lee et al., 2015) and 3) six small humanin-like peptides (SHLPs 16), also encoded by the 16S rRNA region (Merry et al., 2020)