The gut
Reimann F, Diakogiannaki E, Hodge D, Gribble FM
The most commonly used peptides in longevity medicine include growth hormone secretagogues like sermorelin and ipamorelin (for muscle preservation and sleep), BPC-157 (for tissue repair), thymosin alpha-1 (for immune function), and GLP-1 receptor agonists like semaglutide (for metabolic health)
The anti-inflammatory effects and observed improvement in psoriasis and HS after GLP-1RA treatment opens the possibility of studying their therapeutic potential in other common inflammatory skin conditions such as bullous pemphigoid, lupus erythematosus, and atopic dermatitis
Among these, glucagon-like peptide-1 (GLP-1) receptor agonists, which are already approved for weight management and type 2 diabetes, have shown promise
While gastrointestinal effects are well-documented, a growing number of patients and clinicians have begun discussing anxiety a side effect less talked about but increasingly relevant as these therapies expand