In high-fat-diet rodent models, changes in body mass or adipose-tissue measurements may reflect the experimental metabolic endpoint being studied, but safety interpretation is stronger when paired with food intake, body composition, activity, general observations, serum chemistry, hematology, organ weights, and histopathology
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An international team of researchers found that obesity rates for adults had, on average, more than doubled between 1990 and 2022, and more than quadrupled among children and adolescents
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